We aimed to investigate the efficacy of Tanreqing (TRQ) injection on in-hospital outcomes among patients with frequent AECOPD.

This nationwide multicenter registry designed to investigate characteristics, management and prognoses of patients admitted for AECOPD in real-world settings. We collected characteristics, in-hospital prognoses, and CAT, PEACE and mMRC questionnaire from patients. Frequent AECOPD was determined as being admitted to hospital ? 1 or visiting emergency room (ER)? 2 due to AECOPD within a year.

A propensity match method was performed to analyze the efficacy of TRQ on clinical outcomes for inpatients with frequent AECOPD. A total of 4135 inpatients were involved in analysis, including 2179 administered with TRQ and 1956 not. Among those administered with TRQ, 493 had frequent AECOPD and 358 had infrequent AECOPD. After propensity score match, a significant reduction of CAT score at discharge (TRQ median 12; non-TRQ median 13, p=0.0297) and lower rate of ICU admission (TRQ 0.8% Vs non-TRQ 2.6%, p=0.0191) and shorter length of stay (LOS) (TRQ median 11; non-TRQ median 11, p=0.004) were observed in TRQ group among frequent AECOPD. In subgroup analysis, those with PEACE score > 7 on admission, TRQ contributed to significantly lower CAT score at discharge (p=0.0084).  

TRQ injection had better efficacy in patients with frequent AECOPD on reducing ICU admission and alleviating respiratory symptoms, especially those with especially for those with higher severity on admission or more phlegm-heat symptoms.