Comorbidities in COPD have an impact on morbidity and mortality independently of the disease and must be systematically sought and treated correctly. The metabolic syndrome is defined according to NCEP ATP III 2001 by the presence of 03 of the 05 following criteria: Waist circumference ? 94cm, Blood sugar ? 1.10 g/l, Triglycides ? 1.50 mg/dl, HDL ? 40mg/dl and blood pressure ? 130/85 mmhg. Materials and methods: A prospective study of 02 years was undertaken in 2017 which included 183 patients with stable COPD and followed at the tuberculosis and respiratory disease service, . Sociodemographic data, spirometry, comorbidity index, BMI, physical examination with brachial circumference abdomen circumference measurement blood test for: cholesterol; LDL, HDL and triglycerides were performed. Information on the protocol and a consented commitment were obtained for each patient. Results: Mean age 67.07 ± 10.39 years. The distribution according to severity was made according to GOLD 2016 (A, B, C, D). Smoking 28 ± 45 P/A. 6MW 273.79 ± 112.79, Charlson's index 3.99 ± 2.32. Heart disease with 44.7% was the most common comorbidity
46 patients out of the 183  had an métabolic syndrome (25.13%). SM criteria are compared in the two groups (SM+) and (SM -) and an analysis found a significant correlation between SM and age (p= 0.0019). BMI (p= 0.0013) and FEV1 (p= 0.0037). Conclusion: an adapted diet and physical activity or even an effort retraining program are essential measures in any therapeutic action plan for COPD patients.