Introduction:SARS-CoV2 in its most severe form is responsible of acute respiratory distress syndrome.Prognostic scores, like the Pneumonia Severity Index (PSI), can help the clinician to rapidly detect patients with high risk of mortality in community-acquired pneumonia. Would it be the same for SARS-CoV2 Pneumonia? Aim:demonstrate the value of PSI in predicting hospital mortality in case of SARS-CoV2 Pneumonia.Methods: we included 393 patients with SARS-COV2 pneumonia confirmed by RT PCR and/or chest CT, hospitalized in Charles Nicolle Hospital?s pneumology department in Tunis from September 2020 to August 2021. We calculated for each patient the PSI score and we generated the ROC curve with measurement of the AUC. We evaluated the sensitivity and specificity of this score in terms of intra-hospital mortality.Findings:The mean age was 59.8 ± 14.3 [21-91] years. 53.7% were men. Comorbidity was noted in 67.9% of cases. The mortality rate was 23.9%.Patients who died had the higher mean PSI score (89.3±25.7 vs 67.4±22.3, p<0.01). The AUC for this score was 74.7 [69.2-80.2]; 95% CI. The cutoff was fixed at 74.5 with a sensitivity of 71.3% and a specificity of 67%.conclusion:the morbimortality of patients with SARS-CoV2 Pneumonia depends on optimal medical management.The PSI, based on clinical and biological parameters, demonstrated in this study its performance in predicting mortality, making it a reliable prognostic tool.