Background: Therapeutic management of moderate-severe COPD and comorbidities is suboptimal. Pharmacists prescribe medicines but their collaborative interventions are under researched. Aims: To undertake a pilot RCT in Scotland to assess whether: recruitment; retention; intervention; data collection; resource use; clinical outcomes and patient/clinician perspectives support progress to a definitive RCT. Methods: People with moderate-severe COPD in Glasgow and West Lothian were recruited and randomised to Pharmacist home visits (monthly/bimonthly for 12 months, working with Respiratory Physicians, General Practitioners, social care). Pharmacists assessed patients, prescribed and referred to health and social care. Comprehensive baseline data include demographics, medicines; comorbidities; frailty, EuroQol 5D5L; COPD Assessments, Patient Experience with Treatment; and resource use. Parallel process and economic evaluation. Results: 110 recruits (July21-Feb22): 59% female; mean age 67years. Per patient (mean) diagnoses: 2.8 respiratory; 7.6 other physical health; 1 mental health; 11.3 medicines. In the previous year, mean: healthcare contacts=27; costing £5607. 20% reported health states ?worse than death?; 4% reported ?perfect health?. 52/55 received the intervention; 55/55 usual care. 22/110 died; 6/110 withdrawn and 15/24 month follow up is underway. Conclusion: Target recruitment and intervention delivery achieved, full baseline patient characteristics and intervention data will be available for presentation at ERS 2023. Plan to submit final results including clinical outcomes to ERS late breaking trials 2024.