Inflammation plays an important role in chronic obstructive pulmonary disease (COPD). Increasing evidence points to the role of inflammation in the pathogenesis of type 2 diabetes (T2DM). We intend to investigate the biomarkers in Adiponectin, Leptin & IL-8 genes for COPD-induced T2DM patients. Along with this, we analyzed the effect of polymorphism on the levels of these cytokines. A total of 500 subjects including 250 controls, 191 COPD, and 59 COPD with T2DM each, aged 30 to 70 years were enrolled for the study after meeting the inclusion criteria. Written informed consent was obtained from each subject before inclusion in the study. The study was approved by the institutional ethics committee. We found statistically significant results of serum biomarkers in all studied groups. Leptin, Adiponectin, and IL-8 in serum levels were significantly higher with a p-value (0.001)in COPD with diabetes when compared with COPD and healthy controls. Genotype frequency of ?CT? of the Leptin gene variant showed a significant association with the risk of developing COPD by 3.7 folds. But it was not associated witGeh the development of T2DM in COPD cases. Whereas genotype ?TT? was a highly significant association with the risk of developing T2DM in COPD patients by 2.4 folds. This means individuals with genotype ?TT? are at higher risk of developing COPD and moreover they are at risk of T2DM. We also conclude that genotype ?TT? of Leptin, ?GG? of Adiponectin, and ?TT? ofIL-8 may be exploited as biomarkers for prognosis and diagnosis of T2DM in COPD and COPD respectively. While ?CT? of IL-8 was a protective biomarker against COPD.