Objectifs : The aim of this study is to describe the characteristics and the birth outcomes of
women with severe SARS-CoV-2 disease.
Materials and methods : A retrospective collection and analysis of demographic, clinical,
laboratory and pharmacotherapy data on pregnant women with severe pneumonia related
to SARS-CoV-2 infection admitted to our intensive care unit between April and October
2021. 
Results : Seven patients were included in this study. The mean age was 34 ± 4 years. Our
patients had a mean gestality and parity respectively of 2.17 and 1.83. The term of
pregnancy at hospitalization was 29,8 weeks of amenorrhea with extremes of 27 to 32, and
the term of delivery was 30,7 ± 3 weeks?gestation. 42.9% of pregnancies were complicated
by gestational diabetes and 14.3% by preeclampsia. The symptoms presented by the
patients were dyspnea in 100% of cases, fever (71.4%), cough (57.1%) and myalgia (57.1%).
All patients had high-flow nasal oxygen therapy (HFNO) then 57.1% of them required non-
invasive ventilation, and 42.9% were intubated. Corticosteroids and curative anticoagulation
therapy were administered in all patients. Awake prone positioning or prone positioning
was performed in 4 (57,1%) patients. Delivery was by caesarean section in all cases, mainly
due to maternal respiratory worsening in 85.7% cases and due to acute fetal distress in
14.3% cases. The stay in intensive care was 9.8 ± 7 days. Three patients have died due to
complications of COVID-19 showing an ICU mortality rate of 42.9%.

Conclusion: the risk to develop more severe disease is not insignificant with ICU admission associated with maternal morbidity and preterm birth.