Introduction. The International Association for the Study of Lung Cancer (IASLC) Pathology Committee proposed that invasive lung adenocarcinoma be categorized into three subtypes based on histological pattern: well-differentiated (grade 1), moderately-differentiated (grade 2), and poorly-differentiated (grade 3). This grading system has shown to improve prediction of patient prognosis but data among Filipino patients is still lacking.

Aims and Objectives. The aim of the study is to determine the prognostic significance of the IASLC Pathology Committee grading scheme among patients with lung adenocarcinoma in a tertiary hospital in the Philippines.

Methods. We conducted a review of records of all patients with lung adenocarcinoma diagnosed through lung resection between 2017 and 2021. Two pathologists independently reclassified all specimens according to the grading system of the IASLC Pathology committee. Demographics, clinical characteristics, and outcomes were collected. Survival curves were plotted using the Kaplan-Meier method.

Results. A total of nineteen patients were identified. Most were males (63%) and most were non-smokers (68%). Out of the 19 participants: zero well-differentiated (grade 1), six moderately-differentiated (grade 2), and thirteen poorly-differentiated (grade 3). There was no significant difference in overall survival between the moderately-differentiated and poorly-differentiated groups.

Conclusions. The grading system of the IASLC Pathology Committee is not associated with the prognosis of invasive lung adenocarcinoma when it comes to lung cancer across all stages in our set of patients.