Introduction: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report 2023 concluded that approximately 50 percent of smoking and 50 percent of non-smoking factors are responsible for chronic obstructive pulmonary disease patients (COPD). In non-smokers, COPD risk factors include biomass fuel exposure at home, outdoor air pollution, ambient cigarette smoke, dust and fumes at work, poorly managed asthma, history of tuberculosis, respiratory tract infections, and low socioeconomic level. Aims and objectives: We evaluated the risk factors, clinical symptoms, and characteristics of smoking-COPD (S-COPD) and non-smoking COPD (NS-COPD). Methods: Here, we screened 489 COPD patients. Data on socio-demographics, smoking history, risk factors, symptoms, and clinical characteristics were explored. Statistical analysis was performed using the student t-test, the chi-square test, Fischer?s test, and bivariate and multivariate analysis. Results: Out of 489 subjects, 35% were NS-COPD and 65% were S-COPD. In NS-COPD, exposure to biomass fuel was a major risk factor. The majority of the subjects in both groups experienced breathlessness, chest pain, sputum, and coughing. In multivariate analyses, biomass fuel exposure was linked to lower FEV1% in NS-COPD patients. In bivariate analysis, CAT score and illness duration were linked with FEV1%. While in multivariate analysis, CAT score was associated with FEV1% in the NS-COPD group. Conclusions: Our data shows, substantial proportion of NS-COPD in total COPD cases. Exposure to biomass fuel was a significant risk factor in non-smokers and was linked to FEV1%. Additionally, CAT score was linked with disease severity in NS-COPD.