Introduction:

In present ARSVIAA study, we have analysed association of RSV infection, IgE level and atopy in childhood wheezing.

Methods:

Prospective observational study included 384 infants with wheezing and long term follow up RSV RT-PCR status, IgE titer and family history of asthma or atopy. Two groups of 192 cases with RSV RT-PCR positive and 192 RSV RT-PCR negative results at entry point were enrolled. In each group, baseline IgE level and family history for asthma like or atopy, history of recurrent GERD pathology, milk protein, food or environmental allergy were recorded. All cases were analyzed for wheezing pattern as resolution, persistence and recurrence at 2, 4 and 6 years of age. Statistical analysis by Chi test

Results:

RSV RT-PCR positive cases has documented wheezing in 146/192 at 2 years, 94/192 at 4 year and 86/192 at 6 years.(p<0.00001) RSV RT-PCR results (positive in 192 and negative in 192) were analysed with normal (282/394) & raised (102/394) IgE and family history of atopy absent (315/394) & present (69/394) at entry point.(p<0.00001) RSV RT-PCR results as positive & negative were analysed with IgE level as normal & raised & family history of atopy as present & absent with wheezing at 2, 4- and 6-year.(p<0.00001) RSV RT-PCR phenotype, IgE phenotypes and GERD related NANC (non-adrenergic non-cholinergic) phenotype were observed

Conclusion:

RSV infection during infancy causes 'immune dysregulation' which is important trigger for persistent wheezing till 6 years of age. RSV vaccine development is 'important step' in prevention