Asthma is a common chronic respiratory disease in childhood. Several gene studies of this polygenic disease have reported on the role of different SNPs (single nucleotide polymorphism). In this study, it was aimed to investigate the relationship between clinical and biological features (exhaled nitric oxide fraction (FENO), asthma control scales, etc.) used in clinical practice in the follow-up of asthma and the polymorphisms of the FCER2 gene. 99 patients diagnosed with asthma were included in the study. Demographic characteristics and laboratory data, FENO values, blood eosinophil counts (BEC), total IgE, asthma control scales (ACQ), pulmonary function tests (PFT), allergen skin prick tests (SPT), inhaled corticosteroid (ICS) data were recorded. Rs28364072 and rs2228137 SNP in the FCER2 gene were analyzed after signing the informed consent form by the patients or their parents. 38.3% of children with asthma had uncontrolled asthma. Individuals with partially controlled asthma had a significantly lower FENO than the well-controlled and uncontrolled asthma groups (29.3±33.2 and 64.3±73.6; 71±100.1, respectively) (p=0.02). Of the asthmatic individuals, 9 (9.09%) had a homozygous CC variant of the rs28364072 polymorphism in the FCER2 gene, and 5 (5.05%) had a homozygous TT variant of the rs2228137 polymorphism. When the groups were compared, there was no significant difference between pulmonary function test parameters and FENO levels. Solely; BEC (%) level in CC variant of rs28364072 was lower than TT variant (p= 0.005). Although there were no significant results related to asthma follow-up of SNPs in our study, we thought that it contributed to the literature since it was the first study conducted in our country.