HIIT and CLE reduce dyspnea and fatigue in subjects with asthma; however, the effects of both exercise modalities on medication consumption and lung function are unknown. Aim: Assess the effect of HIIT and CLE on SABA consumption and the PEF in subjects with moderate and severe asthma. Methods: Adults with optimized treatment and clinically stable asthma were randomized for HIIT (n=28; 30x30sec; 80-140% of Wmax) or CLE (n=27; 60-80% of Wmax). Exercise training was performed between two medical visits. Both exercises were performed on a stationary bicycle for 12wk, 2xwk, 40min/session. Cardiopulmonary exercise testing (CPET), lung function, medication consumption, and Asthma clinical test (ACT) were assessed before and after the intervention. PEF was assessed before and after all exercise sessions, and SABA was used if PEF<70% before or after exercise. Two-way ANOVA was used for comparison. Results: After the 12-wk intervention, HIIT and CLE improved the percentage of patients with asthma control (ACT>19 score) (46% vs. 44%) and aerobic fitness (peakVO2, 2.0±2.6 vs. 2.5±2.9 ml.kg.min; workload 23±17 vs.16±19 W, p<0.05), respectively. Also, in the first three weeks, no between-group difference was observed in the average SABA use and PEF levels before or after the exercise sessions (p>0.05). However, in the last three weeks, an increase in the PEF in the HIIT after exercise sessions was observed compared with CLE group (358.6±100.2 vs. 302.2±87.8L/sec, respectively; p<0.05). Conclusion: Our results suggest that HIIT induces a greater bronchodilation response during exercise training