Abstract

Introduction: Unexplained exertional dyspnea (UED) is common in non-severe covid survivors(NSCS) implied as deconditioning in most cases. Subclinical heart damage(SCHD), not detected by routine test, may underlie. Post exercise heart rate recovery time (HRRT) may be a marker. We aimed to compare cardiopulmonary exercise test (CPET) indices in 2 groups(Gp) of NSCS with deconditioning and different HRRT. Methods: In a cross sectional study, NSCS with UED underwent(CPET) 6 months after disease. Cardiopulmonary assays including chest image, pulmonary function test and echocardiography were normal. Patients with CPET diagnosis of deconditioning were selected. Upon HRRT, they were categorized into 2 Gp; normal(>20/min) and abnormal. VO2, AT, VE/VCO2, O2 pulse, were compared between 2 Gp. Results: 25 deconditioned NSCS were enrolled  (11  patients in Gp1 with abnormal HHRT?20  ,14 in Gp2 with HRRT >20 ). Mean HRRT was significantly greater than Gp1. Mean Vo2,AT, o2 pulse , ? Vo2/WR  were non-significantly greater in Gp2;while, Vd/Vt in rest and max load were greater in Gp1(details in table1).

index Gp1 Gp2
Age 49.45±12.21 44.43±9.70 0.28
HRRT 17.36±2.20 27.21±4.44 0.00
VO2Max 78.72±9.99 81.85±6.11 0.37
AT 56.14±14.64 59.45±16.36 0.60
O2 pulse 76.45±8.26 82.57±9.71 0.10
?VO2/?WR 10.13±2.60 12.58±3.65 0.06
Vd/Vt rest 0.30±0.04 0.26±0.07 0.11
Vd/Vt max 0.23±0.06 0.19±0.06 0.14
PETCO2AT 35.60±4.86 36.80±5.00 0.55

Conclusion: On a small group of patients, our study supports the hypothesis that HRRT may indicate SCHD in NSCS; further studies with long term follow up and larger groups are needed.