Abstract

Background: While the short-term effects of COVID-19 infection have been  documented. The prevalence, severity, and predictors of long-term outcomes (Long COVID) in intensive care unit (ICU) survivors still poorly defined. Aim: To evaluate the frequency of chronic symptoms in ICU COVID-19 acute respiratory distress syndrome (ARDS) survivors and predictors of  long COVID. Methods: A prospective study performed in a 9-bed medical ICU from Mai 2021 to September 2021 including ICU COVID-19 ARDS  survivors. Patients were reviewed for clinical evaluation 6 months after ICU discharge. Physical, mental, and/or cognitive problems were collected. Univariate analysis was performed to determine predictors of  long COVID. Results: During the study period ,48 patients were included with mean age  48±12 years, and men predominance 28(58.3%). Most reported symptoms were: cough in 7(14.6%) and dyspnea in 24(50%) cases; palpitations in 16(33.3%) cases ;  muscle weakness (20.8%), arthralgia(31.2%), memory disorders (43.8%) and difficult concentration (29.2%). Anosmia, ageusia, hair loss, weight loss, weight gain , and sexual dysfunction were present in  10.4%, 4.2%, 10.4%, 18.8%, 20.8% and 8.3%  of cases, respectively. Among the studied patients, at least 3 of the 6 most frequent symptoms (chronic cough, dyspnea, arthralgia, muscle weakness, memory disorder, and concentration disorder) were observed in 14(31.1%)  patients defining the long COVID. In univariate analysis female gender : 53%  vs 17.8% was the predictive factor of the occurrence of long COVID with p:0.014. Conclusion: Our study demonstrate that long COVID is prevalent among ICU survivors. Female gender was the only predictive factor of its occurrence.