Abstract

Introduction: Several patients suffering from prolonged symptoms (> 3 mo) after SARS-CoV-2 infection feel that their exercise capacity is lowered. We aimed to compare findings in cardiopulmonary exercise testing (CPET) in a cohort of long COVID patients to find out if the subjective exercise capacity corresponds to the patients? objectively measured exercise capacity.Methods: CPET was performed on 95 consecutive patients (mean age 45.1±10.3, range 21-83y) remitted from the more severe end of Helsinki Long-Covid outpatient clinic between August 2021 and December 2022. 54 subjects (56%) felt having lowered exercise capacity (LE-group), and 41 (43%) had several other symptoms but did not report exercise capacity lowering (NE-group). The CPET variables were analyzed using multivariate analysis and adjusted for sex, age, and BMI. Results: The maximal exercise capacity (Wlast4min) in those in LE-group was in mean 82.9% (SD 24.0), without difference from those in NE-group (88.1 %, SD 24.6). Maximal oxygen uptake was 77.4% (SD 19.2), slightly lowered in LE-group, but no difference with NE-group (82.1 % SD 18.9). The first ventilatory threshold was normal without differences between the groups (43.5%, SD 8.1 vs 42.6%, SD 6.8). Oxygen pulse (VO2/HR) was also normal but significantly lower in the LE-group (108.0% SD 26.1 vs 112.3% SD 24.6, p=0.042) than in the NE-group. Conclusion: In patients with long Covid the exercise capacity and maximal oxygen uptake were in mean in normal limits, mainly near the lower limit of normal in those with subjective sensation of lowered exercise capacity. The result might represent less physical activity and unhabituation of it after the disease.