Introduction:

Asthma is the common chronic disease in the world. Asthma not only affected the respiratory status but also made economic burden. The prevalence of asthma has been ranged from 0.8 to 13.4%. Some risk factors had been noticed with smoking, obesity, air pollution and viral respiratory infections. However, asthma-associated metal had not been studied clearly. Nickel compounds are used as extensively in different industrial managements and referred as the generator of oxidative stress.

Aims and objectives:

Neither prominent results nor researches were focused on the clinical outcome of asthma with nickel. We aimed to identify the relationship between urinary nickel level and the status of asthma.   

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Methods:

We analyzed 132 asthma patients with their urine in the tertiary medical center. Demographic data were collected. Asthma patients were divided into high urinary nickel (>2 ?g/L) group and low urinary (= or < 2?g/L) nickel group.

Results:

In high urinary nickel group, there was high blood IgE (521 IU/mL) level compared with low urinary nickel group (blood IgE: 221 IU/mL), p=0.030.

Conclusions:

We identified urinary nickel level was associated with blood IgE level among asthma patients. Further studies were needed to confirm our finding.