Introduction: Many patients with moderate-severe SARS_CoV2 infection have persistent dyspnea affecting their quality of life (QoL).

Aims: assess the influence of supervised physical exercise (sPhE) on: exercise capacity, dyspnea, respiratory function and QoL.

Methods: Pilot Program of sPhE aimed at post-covid patients with persistent dyspnea from a post-covid consultation (Pneum/Rehab HUB). Prospective, unicentric, quasi-experimental, pre-post and crossed (2 periods (P)) study. PhE was supervised by trainers from SielBleu Foundation 1h/week, 12 consecutive weeks: P1(April-June/2022)-P2(Jul-Sept/2022). Three groups(G): Intervention G (IGc ; Intervention in P1-control in P2); Control G (CGi ; Control in P1 and Intervention in P2) and Control-control G (CcG; patients without sPhE in both P). PFT, 6MWT and QoL tests were performed before and after each Period.

Results: Sixty-eight patients participated from 96 recruited: 29 IGc, 26 CGi, 13 CcG, 23 excluded (spontaneous improvement) and 5 losses. Middle age (63+/-10). >50% women in the 3 groups. sPhE improves distance walked (6MWT) post-intervention compared to pre: IGc +30mts in P1; CGi +34mts in P2, while CcG decreased meters in both P (-19 and -9mts respectively). mMRC dyspnea improved after sPhE compared to control. No statistically signif differences in PFT Post-sPhE were observed. Personal care improved & pain/discomfort decreased after the intervention. Anxiety decreased in CGi in P2 and depression increased in IGc and CGi in P1, decreasing in P2. The 3  groups have performed not-supervised PhE during the 2P (3-4d/week, walking, gym, swimming and cycling).

Conclusions: PhE improves the distance walked and QoL.

Acknowledgments: SielBleu Foundation. European Commission (EaSI Program).