Abstract

Introduction NEHI is the most common type of a rare lung disease spectrum that is known as 'interstitial lung diseases' in childhood. NEHI refers to otherwise healthy term infants that demonstrate tachypnea, retractions, noisy breathing and/or hypoxemia in the first months of life. Diagnosis can be delayed in the quest of other more common lung diseases. 

Aims and objective We aimed to address the approach of NEHI diagnosis during Covid-19 era using chest HRCT as diagnostic criteria

Methods Infants presented with manifestations compatible with interstitial lung disease during the early period of Covid 19 pendemic. Infants with other diagnosis such as prematurity, neurological diseases and genetic or complex diseases were excluded. NEHI was investigated with HRCT of the lungs. NEHI clinical score was also recorded. 

Results Altogether three full term infants presented with sustained tachypnea, retractions, and crackles, without hypoxemia. NEHI Clinical Score was 8 in all cases. Chest x-ray presented no specific changes and chest HRCT demonstraded groung glass opacities, which were most prominent centrally, and in the right midlle lobe and lingula. Imaging strongly suggested the diagosis of NEHI. During the next two years, all infants exhibited remarkable progress, with only occasional mild tachypnea. 

Conclusion During the 'foggy' period of Covid-19 pandemic, we experienced the great overuse of medical resourses in favour of SARS-CoV-2 infection. As a result, further simple or complex workups  were extremely difficult to execute. Probably HRCT can be the cardinal diagnostic examination of NEHI, without necessarily using other tests to exlude more common diseases, making diagnosis simpler and less costly.