Background: Evaluating subjective cough outcomes can inform response to treatment. Objective: To evaluate the effectiveness of treatment using patient reported outcomes (PROs) in patients referred to a specialist clinic with chronic cough (CC). Methods: We performed an interim analysis of data collected in a single-centre, prospective observational cohort study of patients referred to secondary care for investigation and management of CC. Patients received therapy based on their underlying cause for CC, or if they had RCC/UCC. We evaluated patients? cough quality of life on the Leicester Cough Questionnaire (LCQ) and cough severity on the Visual Analogue Scale (VAS) before and after treatment. Results: We recruited 44 patients with CC (29 females; mean (S.D) age, 56.8±13.8 yrs, cough duration 9.5 yrs). Patients reported improvements in cough PRO after treatment (VAS mean difference:17.99mm lower post-treatment [95% CI: 9.81 to 26.17 lower, p<0.0001 (Fig. 1A) and LCQ mean difference:2.75 higher post-treatment [1.59 to 3.91 higher, p<0.0001) (Fig 1B). 20/44 patients reported no important improvement on the global rating of change (GROC) scale. Conclusions: Guideline based treatments led to within-patient changes in cough PROs, although 45% reported no important improvement. This demonstrates a large unmet need to develop new treatments.