Aim: to study markers of immunological and non-invasive inflammation (total immunoglobulin E, secretory immunoglobulin A, nitrogen and carbon oxides in exhaled air) depending on smoking status.
Materials and methods of research: an anonymous survey was conducted in colleges in Tashkent and the Tashkent region among 1819 adolescents and youths in order to identify the factor of smoking, respiratory complaints and study the nature of inflammation. Markers of inflammation and function of external respiration were studied. Results of the study: the prevalence of smoking among young people of the organized population was 17.7%. A correlation was found between active smoking among young people and respiratory symptoms, especially a high correlation with respiratory failure and wheezing (c/c=0.801), respiratory failure through the nose (c/c=0.785), while in young passive smokers with allergic rhinitis (c/c=0.721) and allergy (c/c=0.698).
It was found that there is a correlation between the concentration of nitric oxide in the exhaled air and immunoglobulin E has an average level of activity for active (r=0.342) and passive smokers (r=0.479), and for non-smokers this process, as it was determined, has an inverse correlation (r=-402), but with FEV1 we observed a moderately positive correlation (r=0.512). However, in passive smokers, a correlation was found between nitric oxide and secretory immunoglobulin A (r=0.506).
Conclusions: The study of these inflammatory markers is useful for the prevention of diseases of the respiratory system, such as bronchial asthma and COPD, associated with smoking from an early age.