Background: Tobacco addiction is a cause of global health problem with more than one billion smokers globally.

Aim: This study aimed to investigate the association of nicotine dependence with lung function, physical activity and sleep quality.

Methods: It was a cross-sectional comparative study including 87 patients referred to Pulmonary Functional Tests Department of Abderrahmene MAMI Hospital (August to December 2022).Levels of nicotine dependence, physical activity, sleep quality and lung function were assessed using respectively the Fagerström questionnaire (FQ), Short Physical Performance Battery (SPPB), Pittsburgh Sleep Quality Index (PSQI) and a spirometry with measurement of Forced Vital Capacity (FVC) and Forced Expiratory Volume in one second (FEV1).Patients were divided into  2 groups according to (FQ): G1: 48 patients with high level of nicotine dependence (FQ ? 6) and G2: 39 patients with a low-moderate level of nicotine dependence (FQ < 6).

Results: The mean age was 58.98±11 years old. Patients in G1 have a significantly higher number of cigarette packs consumed per year (G1: 56.27±20.28 vs G2: 37.85±20.28; p=0.001).G1 had poorer quality of sleep (PSQI: 6.42±2.37 in G1 vs 4.21±2.37 in G2; p<0.0001) and physical capacity (SPPB: 8.79±1.42 in G1 vs 9.44±1.56 in G2; p=0.049) than G2.When comparing lung function between the 2 groups, we found that FEV1 was significantly lower in G1 than G2 (64.39±23.4 % in G1 vs 75.25±21.70 % in G2; p=0.028).

Conclusion: Smoking behavior and High levels of nicotine dependence has a negative impact on  lung function, physical activity and quality of sleep.