Background: Research suggests that vaping raises oxidative stress levels, is associated with increased disease risk, and has been implicated in poor mental health. 
Objective: To assess cross-sectional associations between quality of life (QOL) indicators and e-cigarette (EC) use in young Canadian adults. 
Methods: We used data from the Canadian Health Measures Surveys. We compared physical activity (daily steps), physiological measurements, self-perceived stress, mental health and QOL between EC users (ever) and non-users (never). Multivariable binary or ordinal logistic regressions were used to calculate odds ratios (OR) and 95% confidence intervals (CI). 
Results: Analyses included 905 participants (15-30 years) with 115 (12.7%) reporting EC use and 790 non-users. After adjusting for confounders, comparing to non-users, EC users had significantly higher odds of being physically active (OR=2.19, 95%CI:1.14-4.20) but also with self-reported extreme chronic stress (OR=2.68, 95%CI:1.45-4.92). Albeit statistically non-significant, EC users also had higher odds of poorer QOL (OR=1.12, 95%CI: 0.64-1.95), but lower odds of other health morbidities (including high blood pressure, blood sugar or lower level of high-density lipoprotein). No statistically significant interactions between EC use, cigarette smoking, weed consumption and health outcomes were observed. 
Conclusion: Our study found that EC use was independently and significantly associated with increased odds of chronic stress and an indication of poorer QOL. Ongoing surveillance of young EC users is important to measure the long-term impact of vaping on their physical, mental health and quality of life and target for interventions.