Background: The medium and long-term impacts of COVID-19 in patients with pre-existing airways diseases are unknown.

Aim: To assess recovery and HRQoL in airways diseases patients up to 1 year post-hospitalisation.

Methods: PHOSP-COVID is a prospective multi-centre UK study of hospitalised COVID-19 survivors who attended 2 research visits at 5 months & 1 year post-discharge. Recovery assessed by answering Yes/No/Not sure to ?Do you feel fully recovered from COVID-19?? HRQoL assessed by EQ5D5L Utility Index (UI) at both visits and a pre-COVID recall estimate.

Results: Overall, 479/2100 (22.8%) had pre-existing airways diseases. At 1 year, perceived full recovery was: 20.4% `Yes`, 55.8% `No` and 23.8% `Not sure` vs 33.2%, 46.1% and 20.7% respectively in the non-airways group (p<0.001). EQ5D5L UI dropped from a mean of 0.74 (0.27) pre-COVID to 0.62 (0.28) at 5 months and remained unchanged at 1 year 0.64 (0.27) compared to 0.84 (0.21), 0.73 (0.24) and 0.73 (0.25) in the non-airways group. Delta change between the 2 groups from pre-COVID to 1 year was -0.09 (0.24) vs -0.11 (0.22) p=0.351. Patients with COPD had lower baseline HRQoL compared to asthma and non-airways groups.

Conclusion: Only 1/5 of patients with pre-existing airways diseases felt fully recovered at 1 year and despite reduced baseline HRQoL, the magnitude of decline was similar to the non-airways group.