Aim
To identify clusters of patients with non-CF bronchiectasis (NCFB) based on etiology, clinical and paraclinical features (age, gender, imaging and disease severity, bacterial colonization) and to establish their relationship with outcomes.

Methods
The method of principal components analysis was used for the hierarchical clustering of NCFB adult patients. Kaplan-Meier method was applied for survival analysis in different clusters.

Results
448 NCFB patients (57% men, 41% smokers) were enrolled (2014-2019) and followed up for 36 months. The most common cause of NCFB was previous infection (35%), followed by idiopathic (30%) and BR associated with COPD (18%). An association with the bronchiectasis (BR) etiology for each phenotype was noted. Phenotype 1 was characterized by idiopathic etiology, predominantly women, elderly, frequent exacerbators, non-smokers, hight disease severity, cystic pattern, severe obstructive syndrome, lobar/segmental atelectasis, hemoptysis, P.aeruginosa colonization and an increased risk of death. Phenotype 2 was characterized by post-infectious etiology, predominantly women, young age, non-smokers, moderate severity obstruction, low risk of death. Phenotype 3 was characterized by COPD associated BR etiology, predominantly male, elderly, smokers, frequent exacerbators, high comorbidity index and increased risk of death. Phenotype 1 has the highest death rate compared to the other two phenotypes (HR:2.0; 95%CI:1.17-3.4). Phenotype 3 presented a higher risk of death compared to phenotype 2 (HR:1.64; 95%CI:1.11-2.42).

Conclusion
Cluster analysis revealed 3 phenotypes with various etiological, clinical and paraclinical features and with a different prognosis in long-term outcome.