Objective: This study was aimed to investigate the effects of bariatric surgery on adiponectin, leptin, interleukin-13 (IL-13), microRNA-192-5p (miR-192-5p) levels and asthma control in obese asthma patients.

Materials and methods: The patient group included 27 participants who underwent bariatric surgery, where 12 were obese patients with asthma and 15 were obese patients without asthma. The microRNA-192-5p was studied by RT-PCR, while adiponectin, leptin, interleukin-13, total IgE, and hemogram was studied by ELISA. 

Results: Significant weight loss was detected in both groups at 6 months after the operation. Both preoperative (0.52 ± 0.29; p<0.001) and postoperative (11.76 ± 28.53; p=0.005) 2-?CT (miR-192-5p) values of the asthmatic obese group were compared to the preoperative obese group (29.20 ± 39.07) and was found to be significantly lower. After bariatric surgery, a significant difference was found in the fold change of miR-192-5p expression in the asthmatic obese group (2.04) compared to the obese group (1,23)(p=0.001). Preoperative and postoperative adiponectin levels were found to be significantly lower in both the asthmatic obese and obese groups compared to the control group. There was a significant increase in ?FEV1 and ?FVC values after the operation in the asthmatic obese and obese groups. There was a significant increase in ACT score and a significant decrease in asthma severity level after the operation.

       Conclusion: Although bariatric surgery causes significant weight loss, it has a significant effect on miR-192-5p levels in providing asthma control in obese individuals with asthma.