Superior vena cava syndrome (SVC) is the complete or partial obstruction of the superior vena cava.

We report 145 cases that we have collected in the department of respiratory diseases from January 2010 to January 2022. The aim of this work is to draw up the different etiologies of SCS.

The average age was 55.1 years with a clear male predominance. Active smoking was found in

92% of the cases. DBS was associated with dysphagia in 8.9% and dysphonia in 9.6% of cases.

 Chest radiography showed mediastinal enlargement in 52% of cases and parenchymal involvement in 48%. The thoracic CT scan showed mediastinal adenopathy in 32% of cases.Mediastinal adenopathy in 32% of cases, a mediastino-pulmonary process and a mediastinal process in 29% each in 29% of cases, and an isolated superior vena cava thrombosis in 10% of cases. The bronchoscopy showed tumor infiltration in 33.5% of cases and extrinsic compression in 22.1%.

Extrinsic compression in 22.1% of cases and tumor stenosis in 18%, hyperhemic mucosa bleeding on contact in 26.4% of cases. Bleeding on contact in 26.4% of cases. The diagnosis was made by bronchial biopsies in 31.1%, by pleural biopsy in 10.8%, by transparietal biopsy in 18.6%,

by mediastinoscopic biopsy in 10.3% of cases, and by peripheral lymph node biopsy in 8%

The etiology was dominated by small cell carcinoma in 34% of cases, hematological malignancy was noted in 24% of cases.malignancy was noted in 24% of cases and in 17% the etiology could not be confirmed.The treatment was based on corticosteroid therapy in 90% of cases and anticoagulants in 40% of cases>The evolution was favorable in 23.3% of the cases, we deplore a death in 35% of the cases. 38% of patients were lost to follow-up