Abstract

Introduction:Cancer is a risk factor for the development of venous thromboembolic disease(VTE).The development of VTE is multifactorial involving patient,tumor and treatment related factors.Objective:The aim of the study was to describe the characteristics of VTE in lung cancer patients.Methods:Retrospective descriptive study conducted in the pulmonology Department IV of Abderrahman Mami hospital of Ariana in Tunisia,including 61 male patients admitted between 2016 and 2023 for lung cancer confirmed pathologically.The diagnosis of VTE was based on imaging findings.Clinical and radiological features were assessed.Results:VTE was found in 1% among 6000 lung cancer patients.The median age was 62±10 years.All patients were smokers.The comorbidities were commonly:Hypertension(20%), chronic obstructive pulmonary disease(18%) and diabetes(16%).Overweight was found in 21% of patients.The performance status scale was 3/4 in 9 patients.The main pathological types were adenocarcinoma(44%),squamous-cell carcinoma(21%) followed by small-cell carcinoma(8%).Fifty-four percent of patients were diagnosed at a metastatic state.Among VTE,43% had pulmonary embolism,10% had superficial venous thrombosis and 49% had deep venous thrombosis.Venous thrombosis was detected in the upper limb in 20% of patients.The patients were treated with Low molecular weight heparins(50%),oral anticoagulants(18%)and Vitamin K antagonist(31%).The delay between VTE and lung cancer diagnosis was a median of 1 month.Death rate was around 15%.Conclusion:The development of VTE in lung cancer patients is a major aggravating factor, increasing the mortality.Larger-scale studies are needed to establish clear guidelines for preventive anticoagulation.