Introduction:
Reports on the effectiveness of directed antibiotic therapy for Pseudomonas aeruginosa (PA) infections in Primary Ciliary Dyskinesia (PCD) are limited, leading to a lack of specific guidelines.

Aims and Objectives:
The objective of this study is to describe the prevalence and duration of PA infections in PCD patients and the corresponding directed antibiotic treatments through a retrospective review of historic patient charts.

Methods:
Microbiological data from a central database between 2010-2018 were extracted, and patient charts were manually reviewed to determine the decision to treat, choice of antibiotic regimen, and its duration. Infection states were described using modified Leeds criteria.

Results:
The cohort showed a 24-35% annual prevalence of PA infections, with 31% of patients developing persistent infections lasting a median of 6.9 years. Meropenem and Tobramycine were the most commonly used intravenous antibiotics, with Piperacillin/Tazobactam being less commonly used. Patients with persistent infections received a median of 8.5 intravenous antibiotic courses. Successful eradication according to the modified Leeds criteria was achieved in 70% of cases.

Conclusions:
PA infections are widespread in PCD patients and often require multiple courses of intravenous antibiotics for long-term infections, although eradication is possible in most cases. Specific guidelines for directed antibiotic therapy for PA infections in PCD are required.