Introduction:LC trends show a strong divergence by sex&age over the years and marked differences in smoking habit and histological subtyping.Aim:To review available epidemiological data on LC incidence in Central Greece, identify age trends and interpret potential changes based on evolving societal circumstances. Materials and methods:Retrospective registry review in 3 tertiary hospitals(2 in Athens metropolitan area,1 in Central Greece)(regional hubs).Review of LC age trends during the period 2015-2020. Results: There is no unified LC registry in Greece;data is limited and is optionally collected. Mean annual LC diagnosis among the 3 hubs is 2216 cases with 90% cases diagnosed in Athens&male predominance.Annual LC incidence in Athens has increased by 20% between 2015-2020 & by 10% in central Greece.At the beginning of COVID19 pandemic LC diagnosis has significantly decreased in central Greece (-30%)versus Athens(-12%)which was attributed to the restructure of healthcare services. Until COVID19, there was an increasing trend in LC diagnosis in 46-50y(5% increase)which has ceased during the pandemic probably due to underreporting and under-presentation in LC services.There is an overall trend of increased LC diagnosis in the elderly population(10%)attributed to investigations for other comorbidities that result in incidental LC diagnosis while younger ages diagnosis remains stable.Conclusions:Greece is lacking a national LC registry and attempts are limited to institutional initiative however based on regional hub registries there is an increasing trend in LC cases diagnosis over the last 5y with a minor drop at the beginning of the COVID19 pandemic.LC diagnosis involves more elderly population while younger ages are stable.