Introduction: COPD is associated with an increased level of inflammatory markers.The aim of this study is to assess the relationship between biomarkers levels in COPD and their association with COPD severity.

Methods:  it was prospective cross-sectional study including 40 patients with stable COPD (group 1) and 40 control patients (group 2). Blood samples of interleukine-6 (IL-6), Tumor necrosis factor alpha (TNF-?) and spirometry were performed and compared.

Results: The mean age of patients (group 1), (group 2), were 63.7 ± 3.9, 55.2 ± 6.3 years, respectively (P > 0.05) with an average intoxication of smoking  load 39.5 ± 5.3 versus 27.4 ± 4.7 pack-years.The patients of group 1 were classified according to FEV1 to group I, II III,IV in respectively 20%, 30%, 26% and 24%. IL-6 levels were elevated in COPD patients who smoked more than 45 pack-years (74.97±34.81 pg/mL ; P=0.0005) and respectively higher in COPD groups IV and III: 233.6 ± 70.2 pg/ml, 180.5 ± 26.8 pg/ml. TNF-? levels were found to be 78.8 ± 21.6 versus 20.7 ± 7 pg/ml and respectively higher in groupe III (75.8 ± 20.6 pg/ml) and groupe IV (46.3 ± 15.7 pg/ml). Higher levels of IL-6 and TNF-? occurred in COPD groups with body mass index <22 kg/m2 (p=0.002), more than two exacerbations in the past year (p=0.01), and higher smoking burden. A positive correlation between IL-6 concentrations and a more rapid decline in FEV1 has been founded(r=0,564),

Conclusion: The relationship between interleukins and COPD severity has been found.Further studies to explore the relationship between COPD and interleukins should been used evaluated.