The study aimed to determine the prevalence of RS and PF in pts with various CLPDs in Dnipro (Ukraine).

Methods and study population. In prospective single-center study pts with any CLPDs were included. Clinical examination, mMRC and CAT, analysis of chest CT to determine the presence of intrathoracic lymphadenopathy (ITLAP) were performed; PF was determined by spirometry, bronchodilator test (BT) was performed in pts with obstruction (O). Pts with pneumonia were excluded. 

Results. 90 pts, mean age 64 (56-70),  40 (44.4%) - women, were included . 46 patients (51.1%) had chronic lymph
leucosis CLL, 21 (23.3%) had a multiple myeloma (MM); 23 (25.6%) had lymphomas (L).

37.8% of pts had RS, but only 4.4% of pts had diagnoses of respiratory comorbidity (RC). 54.4% of
pts had PF disorders, and 81.6% of them had only O or mixed disorders with a predominance of
O (52.5%mild, 37.5%moderate, 10%severe O); 12.5% of pts had positive BT. FEV 1 /FVC was
found to be significantly lower in pts with MMthan in pts with CLL and L; however, the proportions of pts with obstruction were equivalent in the groups. 42.2% of pts had ITLAP. The presence of ITLAP in pts
with L was significantly associated with a lower FEV 1. 

Conclusions.

The obtained results indicate the need for a thorough respiratory examination, including chest CT and spirometry, in all pts with CLPD, even in the absence of known RC. The presence of O and ITLAP are among the main factors that affect the severity of RS in CLPD, therefore, such pts require careful diagnosisand, in the presence of O, prescribing of broncholytics.