OSA is often associated with decreased Health-Related Quality of Life (HRQoL). In a prospective one-year follow-up study, we assessed at baseline and after PAP therapy the HRQoL and the psychological profile in 101 OSA patients (22 F; mean age 56.3±10.5 years). We observed at baseline the presence of moderate to severe anxiety symptoms in 18,7%  and depressive symptoms in 11.9% of patients.  Fifty-nine patients completed the follow-up (mean age 58.7±10.4, 11 F): 86.4% of them were adherent to PAP therapy. We found after a 1-year follow-up, a statistically significant improvement in anxious symptoms (6.8±3.6 vs 5.4±3,8, p=0.001), in HRQoL (70.4±19.0 vs 79.2±20.3, p=.001), in satisfaction for sleep quantity (52.3±31.7 vs 71.4±26.2, p=.001), sleep quality (52.3±31.7 vs 71.4±26.2, p=.001), mood 58.5±24.9 vs 71.0±25.6, p=.001), physical resistance (61.6±28.4 vs 67.8±27.4, p=.039) and colleagues relationship (68.5 ±23.1 vs 76.8±21.5, p=0.02).  We noted a different pattern of improvement according to baseline severity of quality of life impairment: the lower the level of HrQoL at the baseline, the higher the degree of improvement in the follow-up (r=0.47; p=0002). In conclusion, the impact of PAP treatment on patients? psychological and HRQoL evaluations provides valuable data to unveil different profiles characterizing this clinical population.