Background: SARS-CoV-2 physiopathology is linked to an uncontrolled response of the immune system besides a hyper-coagulopathy status.

Aim: To characterize phenotypes according to inflammatory and cardiac biomarkers.

Methods: Patients admitted to the Hospital Clinic of Barcelona due to COVID-19 infection between 28^th January and 14^th June 2021 were prospectively included. A blood sample during the first 48h from hospital admission was collected for each patient to measure interleukin (IL)-6 and NT-proBNP. Biomarkers concentrations were quantified by bead-based multiplex assays (Millipore Iberica, S.A., Spain). For the analysis, patients were categorized into four groups depending on inflammation(IL-6<or ?80 pg/mL) and cardiac phenotypes (NT-proBNP <or ?34.3 pg/mL. Clinical information was collected.

Results: One hundred sixty-nine patients were included (Table 1).Cardiovascular comorbidities were more present in the cardiac phenotype. Inflammatory phenotype? patients more frequently presented ARDS, while coagulation disorders were more commonly found in patients with both altered biomarkers. Length of stay, ICU admission and IMV requirement were higher in the inflammatory phenotype, whereas mortality was higher when both phenotypes concurred.

Conclusions: High levels of inflammatory and cardiac biomarkers were associated with poor outcomes in hospitalized COVID-19 patients.