Background: Bronchiectasis is characterized by irreversible dilatation and destruction of one or more bronchi and the permanent obstruction of the airways by impaired gas exchange mechanism and secretion causes losses in respiratory function, respiratory muscle strength, and functional capacity. Poor patient compliance and low participation rate are among the common problems in patients with bronchiectasis, and video game-based exercises are an effective method to increase patient motivation, compliance, and active participation.

Aim: To compare the effects of video game-based breathing exercises and conventional breathing exercises in children and adolescents with non-cystic bronchiectasis.

Methods: Twenty-six children aged between 8 and 18 years with non-cystic bronchiectasis were randomly allocated to either ?conventional breathing exercises group? (CG) or ?video game-based breathing exercises alongside conventional breathing exercises group? (VG). Both groups trained for 8 weeks. Spirometry, respiratory muscle strength, and 6-min walk distance (6MWD) were assessed at baseline and after 8 weeks of training.

Results: Both groups experienced significant improvements in all parameters of the spirometry, maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and 6MWD (p?<?0.05). The MIP and MEP were further improved in VG compared to CG (p?<?0.05).

Conclusion: The present study showed that while video game-based breathing exercises provide additional benefits in improving both inspiratory and expiratory muscle strength, they did not provide any additional benefit in improving functional capacity.