Introduction: The COVID-19 infection passes through several periods, in which differences are observed regarding some clinical and epidemiological indices.

Aim: to present the latest data on the clinical epidemiological characteristics of hospitalized patients with COVID-19 infection.

Material and methods: 72 hospitalized patients with severe COVID-19 infection were retrospectively analyzed for the period 01.08.2022-31.01.2023, 46 men and 26 women at an average age of 74 years. The infection was confirmed by PCR testing. The frequency of main clinical symptoms was followed. Correlations between outcome of the disease, length of stay, and basic clinical epidemiological indices were sought. The data were processed with Statgraphics v.18.

Results: The most common clinical symptoms were: general weakness ? 100%; dyspnea 84.7% (61); cough 83.3% (60); headache 38.9% (28); sore throat 20.8% (15). Death was found in 19 (26.3%) of the patients. We established a correlation between the mortality and: low antibody titers against SARS- CoV-2 (p=0.009), low oxygen saturation (p=0.0004), more than two comorbidities (p<0.05). 71 of the patients were polymorbid. The patients with ischemic heart disease 64% (46) and hypertension 57% (41) had poor outcome, p<0,05. Unvaccinated people were 91.7% and had a longer period of hospital stay (p=0.007).

Conclusion: The main indices of the disease are typical of its clinical course with slight exceptions. Lack of vaccination is an important factor for hospitalization. Low antibody titers against SARS-CoV-2 and low oxygen saturation are poor prognostic markers for mortality from COVID-19.