Introduction: Lung hyperinflation (LH) has become one of the main concerns in recent years in the management of COPD, as it has important systemic consequences that go far beyond the scope of ventilatory mechanics (1). The aim of this work was to study the impact of LH on the age of the cardiorespiratory and muscular chain in COPD patients 

Methods: Cross-sectional study including 77 male stable COPD patients FEV1/FVC post BD < 0.7. All Patients underwent plethysmography and a six-minute walk test. Two groups of patients were distinguished according to the presence or absence of LH: the non hyperinflared group (IC/TLC > 0.25 (n = 54) and hyperinflated group (CI/TLC < 0.25). Estimated cardiorespiratory and muscle chain age was determined by the following equation (2): (- 31.18 x gender [0.H, 1.F]) - (0.43x Weight [kg] + (52.91 x Height [m]) +140.17

Results: The two groups were matched by chronological age, the mean age was 65±9 years in the hyperinflated group versus 67±7 years in the non hyperinflated group, respectively, with a p=0.34. Smoking consumption (pack/year) was similar in both groups (47±25 vs 40±23 p = 0.204). The mean value of post-BD FEV1 (%) was significantly lower in the hyperinflated group compared with the non hyperinflated group (40±12 vs 60±15 p <0.01). The mean age of the cardiorespiratory and muscular chain (year) was significantly higher in the hyperinflated group compared to the non hyperinflated group (109±13 vs 101±13 p=0.01).The cardiorespiratory and muscular chain age was negatively and significantly correlated with the IC/TLC ratio (r=0.40 p<0.01)

Conclusion:The age of the oxygen transport chain could be influenced by LH