OBJECTIVE: There is a high prevalence of cardiovascular events in the COPD population. There are hardly any references about the comparative effect of the PR on COPDCORI and systemic inflammation, neither about the differences according to the exacerbator or non-exacerbator phenotype in COPD patients.  METHODOLOGY: Prospective and interventional study of two parallel groups of 51 COPD patients, who are referred to a PR programme for an 8-week period. We recorded demographic data, personal antecedents, cardiovascular disease and the patient's history of exacerbations in the last year. A blood test was collected under steady state conditions. CVR was estimated using the Disease Coronaropathy Risk (COPDCoRi). RESULTS:We observed a significant decrease in cardiovascular risk as measured by the COPD CORi after completion of pulmonary rehabilitation. (prePR 53,09 +- 12,86 vs postPR48,52 +- 11,69, p<0,002) If we categorise according to phenotype we found that it is the exacerbator group that decreases CVR the most. (exacerbator: prePR 53.35 +-12,11 vs postPR 47,24 +- 10, p<0,001; non exacerbator prePR 53,78 +- 14,29 vs postPR 50,16 +-13,82 p < 0,08). If we consider that the cut-off point for high cardiovascular risk according to COPD CORI is greater than or equal to 65 and we relate it to the rest of the inflammatory parameters, we do not find significant correlations. CONCLUSIONS: 1- Cardiovascular risk as measured by COPD CORi decreases after completion of a respiratory rehabilitation programme, even more so in the exacerbator group. 2- We found no significance between COPDCORI and systemic inflammation.