Abstract

COPD is the third leading cause of death globally, data in developing world is lacking. However,not only smoking but passive smoking, infections, exposure to indoor and out door pollution are recognized risk factors in these countries and pulmonary hypertension is a common complication that is underestimated and managed. Determing a correlation between FEV1 and Pulmonary artery hypertension will help to identify COPD patients with this complication at an early stage and hence reduce morbidity. A cross sectional study was conducted among COPD patients presented to Pulmonology Department in tertiary care hospital with the objective to determine correlation between FEV1 and PAP (pulmonary Artery Pressure) as determined via Echocardiography. COPD patients of both gender were included.Interestitial lung disease, Chronic heart failure, Pneumonenctomy, Lung Cancer, Primary Pulmonary Hypertension and Pulmonary Vascular disease were excluded. Total of 73 COPD patients with mean age of 57.38±10.30 years were recruited after taking informed consent.Mean duration of COPD was 17.84±7.92 years.Thirty one (42.5%) were males and 42(57.5%) were females. Spirometry and Echocardiography was done to determine FEV`(mean 1.38 ± 0.74liters) and PAP (mean 47.71 ± 20.11 mmHg). Pearson`s correlation was used to determine correlation among these variables. There was a statistically significant, moderate negative correlation between FEV1 and PAP (r = -0.547; P < 0.001). This highlight the risk of development of pulmonary artery hypertension increases with worsening of severity of COPD.