Backround: The benefits of thoracic manual therapy (TMT) in patients were reported. However, its effects are limited in stroke patients. Further research is required in new modalities demonstrating TMT efficacy in stroke patients. Aims and Objectives:The purpose of this study was to investigate the immediate effects of thoracic manual therapy (TMT) on pulmonary function in stroke patients. Methods: Forty-seven patients (33 men, 14 women) were recruited and randomized to a TMT group (n = 31) and a control group (n = 16). All participants underwent initial pulmonary function and respiratory muscle strength tests and then rested supine for 10 minutes before the intervention. The respiratory tests were repeated immediately after the intervention. Tests included: maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP), forced vital capacity (FVC), forced expiratory volume at 1 second (FEV1), FEV1/FVC, and Peak Expiratory Flow (PEF). Results: The TMT group had significantly greater improvement in FEV1, FEV1/FVC, PEF, and MEP compared with the control group (p?<?0.05). FVC, FEV1, FEV1/FVC, PEF, and MEP were significantly improved in the TMT group. Conclusions: This study demonstrated that the TMT group had improved outcomes in pulmonary function and respiratory muscle strength compared with the control group.