Objective: To determine the prevalence and risk factors of sleep disorder and disturbances among chronic obstructive pulmonary disease (COPD) patients. Systematic review was conducted by searching peer-reviewed articles. Observational studies that used the English language published from 2018-2022 were screened. Two reviewers independently searched, extracted data, and assessed each study quality. Assessment was based on the JBI Critical Appraisal Tool checklists. Results: 12 studies in 7 countries out of 461 search results were included, in which most were cross-sectional studies (n=10). Most studies used questionnaires to evaluate sleep disturbances (n=9) while the rest used diagnosis of sleep disorders (apnea/hypercapnia). The pooled prevalence of sleep disorder and disturbances is 23.9% (range:9.2-66.0%). Studies reported that anxiety (odds ratio (OR):4.12;95%CI:2.32-6.44), depression (OR: 3.54; 95% CI:2.43-5.43), and low self-efficacy (r2:0.057,p<0.01) are risk factors for sleep disorder or disturbances. Being female (factor loading:0.642) and age>60 years old (p=0.034) were all the demographic predictors while being physically inactive (p?0.0001) is the lifestyle factor identified. Clinical predictors included previous respiratory failure (OR:1.74;95% CI:1.19?2.53), and being hypertensive (OR:2.01;95%CI:1.551 - 2.470) or diabetic (OR:2.06;95%CI:1.442-2.669). Findings reported a high prevalence rate and different demographic, clinical, and lifestyle risk factors associated with sleep disorder and disturbances among COPD patients. Study results may help design proper clinical approaches to improve sleep quality of COPD patients.