Objective: To assess the phenotypic manifestations of Chronic Obstructive Pulmonary Disease (COPD) with comorbidity of Obstructive Sleep Apnea (OSA) syndrome.

Methods and Materials. 62 patients with COPD were diagnosed with OSA using polysomnography and the degree of its severity was interpreted using the apnea-hypopnea index (AHI). The control group consisted of 34 patients with COPD.

Outcomes: The outcomes of the study showed that patients with COPD and COAGS have characteristic phenotypic features that indicate high risks of the disease affecting their health (75.8%), frequent exacerbations (95.2%) and exacerbations requiring hospitalization (93.5%), as well as significant clinical components of the disease (74.2%) and obstructive disorders (93.5%). As the COAGS worsened, the frequencies of phenotypic features also increased: CAT ?10 increased from 57.7% to 94.7%, the frequency of exacerbations more than 2 times and hospitalizations more than 1 time increased from 92.3% to 100%, MRC ?10 increased from 57.7% to 100%, and OFV1 ?50% increased from 92.3% to 100%. The frequency of phenotypes in COPD with COAGS was as follows: phenotype A was present in 1.6% of cases, phenotype B was present in 4.8% of cases, phenotype C was present in 24.2% of cases, and phenotype D was present in 69.3% of cases.

Conclusion: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a comorbid condition that exacerbates the progression of COPD and is characterized by frequent exacerbations and severe obstructive respiratory events. The presence of OSAHS in individuals with COPD has been shown to contribute to a more severe phenotype of the disease.