Aims:?Urinary Incontinence (UI) associated with refractory chronic cough (RCC) can severely impact quality of life and has been commonly reported by patients. To better understand this burden, we assessed prevalence of UI by two methods in a RCC population enrolled in a phase 2b trial of camlipixant (BLU-5937).  
 
Methods:?Participants enrolled could disclose that they suffered from UI as part of their medical history, and also completed the International Consultation of Incontinence Questionnaire Short Form (ICIQ-SF), a validated measure of severity and impact of UI. 
 
Results: As part of their medical history, 29 (12%) of participants (n=249) reported UI and 17 (7%) reported stress UI. In contrast, out of 213 participants that completed the ICIQ-SF, 117 (55%) reported leaking urine when they coughed or sneezed. Of these, 52% reported leaking urine at least once a day and 31% reported leaking several times a day. Demographic characteristics of participants reporting cough-related UI in the ICQ-SF were similar to those who did not, with the exception that they presented an average ICIQ-SF score of 9.5(4.9), reflecting a moderate UI severity, and a majority (96%) were female. 
 
Conclusions: To our knowledge, this is the first report of cough-related UI assessed by direct vs indirect solicitation in the same RCC population. These results suggest that the actual burden of urinary incontinence in patients with RCC may often be overlooked by routine medical history. Instead, direct query by physicians may provide a more accurate assessment of UI in these patients.