Background: Work productivity and activity impairment (WPAI) are rarely used to evaluate response to cough treatments. This study aims to examine the WPAI scores among chronic cough (CC) patients before and after a guideline-based treatment. Method: In this prospective observational single center study, patients were referred to secondary care for investigation and management of CC. Patients were assessed at baseline including the WPAI Questionnaire, then given a guideline-based treatment and re-assessed within 2 months. Results: 43 patients with CC were recruited (29 females; mean (S.D) age, 56.8±13.8 yrs, cough duration 9.5 yrs). For employed patients (n=26, age 53.5), % absenteeism, % presenteeism (impairment while working) and overall % work productivity loss improved numerically with treatment (Table 1) but did not reach statistical significance. The % activity impairment was greater in older unemployed patients (n=17, age 67.2) at baseline. Both employed and non-employed groups experienced significant improvements in activity impairment after treatment (Table 2). Conclusion: There was a modest improvement in activity impairment due to CC after treatment based on guideline based treatment. More long-term data across different ages and occupations are needed to fully evaluate effects of current and novel cough therapies.