Background: Aerobic and resistance training (ET) is considered a useful and effective complementary treatment for people with lung, head and neck cancer during chemotherapy and radiotherapy (usual cancer treatment - UCT). However, some aspects, such as negative symptoms may interfere on patient?s adherence to the ET, and these aspects are unknown in this population. Aims: To identify the symptoms reported by people with lung, head and neck cancer during the UCT combined to an ET, and to verify if these symptoms interfere in the treatment adherence. Methods: The participants performed the UCT combined to a home-based semi supervised aerobic and resistance ET, that included aerobic (walk based) and resistance training (TheraBand based). A questionnaire developed by the researchers regarding the symptoms experienced on the previous 7 days was completed weekly. Adherence was assessed via the ratio between the number of PT sessions prescribed and completed for each participant, and symptoms frequency was recorded as the number of symptoms reported by each participant. Results: In total, 10 participants were included in the ET program [age 62±10 yr; 8 (80%) males; lung cancer (n=5 (50%), head and neck cancer [n=5 (50%)]. The most reported symptoms were dysphagia (37%), fatigue (35%), anxiety (19%) and malaise (17%). Inverse correlations between adherence and fatigue (p= 0.01, r= -0.74) and sadness (p= 0.05, r= -063) was identified. The training adherence was 55%.Conclusion: People with lung, head and neck cancer, commonly experience symptoms such as dysphagia, fatigue and malaise during UCT which may interfere with adherence to ET.