ERS Respiratory Channel

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Abstract

Background: M1 polarization of alveolar macrophages is one of the main factors of lung inflammation in COPD, and M1 polarization of alveolar macrophages is a key factor for persistent inflammation in COPD. Therefore, finding the key target of macrophage M1 polarization in COPD and inhibiting alveolar macrophage M1 polarization is an effective way to alleviate COPD.

Aim: We established a cigarette-induced COPD mouse model, and explored the key targets affecting the M1 polarization of alveolar macrophages by single-cell sequencing and proteomics.

Results: We established a COPD mouse model through three-month cigarette exposure, then collected lung tissue after sacrifice and performed single-cell sequencing and proteomic analysis. Using bioinformatics to analyze single-cell sequencing and proteomics data, and analyze the possible key targets that affect the polarization of alveolar macrophages. Then, using cell experiments, verify the function of this protein.

Conclusion: Our study shows that AIF1 may be a new key target that can regulate the M1 polarization of alveolar macrophages, and it can inhibit the persistent airway inflammation caused by M1 polarization by inhibiting the expression of AIF1.

Abstract

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