Introduction: N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) is vital for risk assessment in pulmonary hypertension (PH).

Aim: This UK-wide study aimed to assess the agreement of capillary sendaway NT-proBNP with standard venous NT-proBNP, including the effect of delayed processing.

Methods: Patients with pulmonary hypertension were included from UK adult pulmonary hypertension centres. During a single visit, reference venous NT-proBNP samples were obtained. Two capillary samples were contemporaneously obtained and sent to a private laboratory (Thriva) where they were analysed at 3- and 7- days from the day of blood draw. Results were compared by Spearman?s  correlation (r) and Bland-Altman analysis using a logarithmic transformed NT-proBNP against the proportional difference.

Results: Results are available for 63 participants. 41 patients were diagnosed with PAH, 13 with CTEPH and 9 with other forms of PH. The median reference NT-proBNP was 514pg/ml. There was excellent correlation between standard venous with day 3 (r=0.99, p<0.001) and day 7 (r=0.98, p<0.001) capillary NT-proBNP with good agreement at day 3 (figure 1). The mean proportional difference was -5% for day 3 results and -26% for day 7.

Conclusions: These data demonstrate that capillary NT-proBNP may be a valid measure of NT-proBNP in PH, raising the possibility that patients could perform this test at home as part of a telemedicine strategy.