Introduction: Comorbidities influence the prognosis of patients with chronic obstructive pulmonary disease (COPD).COPD patients have poor sleep quality compared to healthy subjects. The aim of our study was to determine the impact of comorbidities in sleep quality in patients with COPD.Methods: it is a cross-sectional study conducted in department 1 of pneumology. We included patients with COPD from January 2022 to June 2022.Sleep quality was evaluated by the PSQI questionnaire in stable patients for at least 3 months. Patients with obstructive sleep apnea were excluded. Results: One hundred patients were enrolled. The mean age was 65.63 years (43 to 97 years). A median PSQI score was six (3-9.75).  We noted that 37% of the population had poor sleep quality (PSQI score ?5). We counted 68 patients (68%) with comorbidities. The absence of comorbidity was not significantly correlated with good sleep quality. The most frequently reported comorbidity was hypertension (29 cases) followed by: anxiety (21 cases), diabetes (18 cases), bronchiectasis (14 cases), ischemic cardiopathy (9 cases), depression (7 cases), asthma (6 cases) and osteoporosis (2 cases). Hypertension was correlated to poor sleep quality (p=0,004) with poor subjective sleep quality (p=0,048)and poor form during the day(p=0,023). Osteoporosis affected sleep quality and was correlated to sleep latency (p=0,015). Diabetes was correlated to poor sleep quality (p=0,04).Conclusion: There is a strong relationship between the presence of comorbidities and poor sleep quality in patients with COPD. This demonstrates the importance of treating comorbidities to improve the quality of life of these patients.