Sarcoidosis is a multiorgan disease with predominant lung manifestation and usually a good prognosis, however, there are clinical situations significantly affecting survival (heart, central nervous system, or kidney involvement).

The aim of the study was to assess survival and find possible risk factors for mortality in a big cohort of sarcoidosis patients observed over 11 years.

Methods: retrospective analysis of the group of patients diagnosed with sarcoidosis in the tertiary reference center for lung diseases. The analysis covered the period between January 2009 and March 2020. Clinical data (extent of disease) and lung function tests (spirometry and lung transfer factor for CO - TLco) results at the first presentation were included in the statistic model. 

Results: data from 2625 sarcoid patients were collected. At the first presentation: age 43.5±11.8 years, 58% males, the majority of patients (65%) were at stage 1 (only lymph nodes), 23% of patients had stages 2-4, in 12% multiorgan disease was diagnosed. Lung function tests revealed airway obstruction in 17%, possible restrictive pattern in 13%, and low lung transfer factor in 22% of these patients. The median observation time was 7.4 (IQR 4.1 to 9.9) years. Only 74 patients (2.8%) died in the observed period. Survival analysis revealed that the baseline extent of the disease was not associated with prognosis. The multivariable model (Cox hazard ratio) indicated that age and impaired TLco (OR 2.6), but not the extent of the disease, nor spirometry results at the time of the first presentation were independent factors associated with overall mortality.

Conclusion: Mortality in sarcoidosis is generally low and associated with age and low TL,co