Introduction: Sarcoidosis and its comorbidities can pose a threat to the patient, require rapid initiation of treatment and justify emergency hospitalization. Methods: The objective of our retrospective monocentric study was to describe the causes of emergency hospitalization in sarcoidosis patients and to identify predictors of mortality of these hospitalized patients. We included patients admitted at our referral center after a stay in the emergency room or in the intensive care unit or during an unplanned hospitalization after a telephone advice or a consultation, between 01/01/2017 and 07/07/2020. Results: Among 410 sarcoidosis patients admitted during the study period, 154 patients were hospitalized in emergency, of which 14 (9%) patients stayed in the intensive care unit. The median age was 55.0 [44.0; 67.0], 87 (56%) patients were under corticosteroids and 36 (23%) under immunosuppressive agents. Sarcoidosis was inaugural in 20 (14%) patients. The primary reasons for hospitalization were lower respiratory infections (n=32, 21%), followed by respiratory exacerbations of sarcoidosis (n=17, 11%), cardiac (n=13, 8.4%), central nervous system (n=12, 7.7%). In-hospital mortality was 3.9%. The median length of stay was 6 [3.00; 10.0] days. The 5-year survival following hospitalization was 73.1% (63.1%; 84.7%). The predictive factors of overall mortality were invasive ventilation (HR= 77.61, 95%CI[12.39-486.16], p<.001), DLCO (HR=0.95, 95%CI[0.92- 0.98], p=0.002) and age (HR=1.10, 95%CI[ 1.04- 1.16], p<.001). Conclusion: The causes of emergency hospitalization in sarcoidosis patients are various, and the overall mortality of hospitalized patients is high.