ERS Respiratory Channel

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Abstract

INTRODUCTION

The aim of this study is to determine whether the 6-minute walk test (6MWT) can predict potential desaturation during sleep in patients with COPD

METHODS

This cross-sectional study included patients with COPD and moderate hypoxemia (SpO2 >93%), who underwent a 6MWT and continuous oximetry monitoring during sleep.The desaturation area was calculated by adding the difference between the values observed in the baseline SpO2 and every 2 minutes during the 6MWT. The desaturation-distance ratio (DDR) was defined as the value obtained by dividing the desaturation area by the distance walked in meters. The percentage of recording time with SpO2<90% (T90) was determined during both the 6MWT and sleep, and a T90>15% was considered clinically significant for nocturnal desaturation

RESULTS

A total of 113 subjects were included, 93were men(82%), average age of 62±6.4 years and a FEV1postbronchodilator 52±17%.The 6MWT showed desaturation in 40 patients (35%) and nocturnal desaturation was observed in 39 (34.5%),compared to subjects without nocturnal desaturation no clinical or functional differences were observed, except for mean, minimum and last SpO2 during the 6MWT(p<0.001).Nocturnal desaturation (T90>15%) and variables related to SpO2 during the 6MWT, includingT90, desaturation area and DDR (p<0.001),were found to be significantly correlated.The receiver operating characteristic (ROC) curve showed a good level of discrimination

CONCLUSIONS

The prevalence of desaturation during exercise and nocturnal desaturation is high in COPD patients without severe hypoxemia. The results of the 6MWT can provide clinical information to predict nocturnal desaturation.

Abstract

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