INTRODUCTION:The global estimate of cardiovascular risk (CVR) is considered the best tool to establish priorities in the prevention of cardiovascular disease. In COPD population, we know that inflammation is associated with more exacerbations and worse prognosis. We hypothesised to develop a new inflammatory-SCORE with various parameters to relate the inflammatory milieu with phenotypes and cardiovascular risk.  METHODOLOGY:This cohort study included 50 COPD patients. Demographic data, personal history and history of exacerbations in the past year were recorded. Inflammation was assessed by different inflammation-SCORE based on 5 biomarkers (ApoB48, eosinophils, fibrinogen, TBARS and hs-CRP). The data were divided into 10 deciles, and each decile was assigned a score, from -4 to -1 the lowest and 1 to 4 the highest. CVR was further analysed with QRISK3, SCORE, SCORE2 and Framingham to correlate with the new inflammatory score.  RESULTS:We found that exacerbating patients have a higher inflammatory-SCORE than non-exacerbating patients, although without reaching statistical significance (2.44 ± 6.3 vs  -0.33 ± 5.2, p =0,120).We correlated the SCORE-inflammatory  with SCORE (r=0.277; p=0.054) SCORE2 (r=0.455; p=0.017), QRISK3 (r=0.430; p=0.002) and Framingham (r=0.304; p=0.034). We observe that the correlation values between the inflammatory score and the different risk scores are favourable.CONCLUSIONS: 1-The exacerbator phenotype shows a higher inflammatory SCORE than non-exacerbator patients.2- The inflammatory-SCORE could be a useful tool to assess CVR in COPD patients or even predicts future cardiovascular events.